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Using CRISPR/Cas9 technology with sgRNA 5'-CTCTTTGCAGGTCCATCGGC-3' and a 121-bp single-stranded oligodeoxynucleotide (ssODN) template, a c.1580A>G point mutation was generated to change histidine codon 527 to an arginine codon (p.His527Arg). This mutation mimics the p.His530Arg mutation found in some human familial Wolff-Parkinson-White (WPW) syndrome patients. (J:278059)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
