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A 4-base deletion (c.435_438delCCGG or c.439_442delCCGG) was created in exon 2 with two sgRNAs and a donor oligonucleotide using CRISPR/Cas9 technology. This deletion mimics one found in a family with patent ductus arteriosus (PDA). (J:278067)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
