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A mutation was engineered to change glycine codon 422 to a serine codon (p.G422S). This change renders the peptide subject to phosphorylation at that residue and thus makes it more similar to homolog Crebbp, which has a serine at the equivalent position (S436). A self-excising ACN cassette (comprising a loxP site, testes-specific elements of mouse Ace gene, a modified Cre gene with SV40 intron and HSV polyadenylation signal, a neomycin resistance gene cassette, and a second loxP site) was inserted into intron 5. (J:278697)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
