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The loxP sequence and Neo cassette flanked by two frt sites were inserted into a site 331 bp upstream of exon 12. An internal ribosomal entry site (IRES) sequence and splice donor (SD) sequence from exon 8 of the mouse Hprt gene were inserted downstream of the Neo cassette for the poly-A trapping strategy. The other loxP site was introduced into a site 185 bp downstream of exon 12 to eliminate the putative transmembrane domain after Cre-mediated recombination. (J:279639)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
