A loxP site was inserted upstream of exon 5 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. The neomycin selection cassette was removed via Flp-mediated recombination. (J:151612)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count