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A 104bp deletion, which contains the entire precursor-miR-185 encoding sequence, was deleted by CRISPR/Cas9 genome editing technology. The deleted sequence lies within intron 1 of the overlapping Tango2 gene; however, real-time PCR analysis indicated that Tango2 expression in homozygous mutant mice was unaffected. (J:278853)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
