This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences AGAGGAAGAAATCATAATGC and ATTGATTTCCTACATCACGG, which resulted in a 267 bp deletion beginning at Chromosome 19 position 26,646,911 bp and ending after 26,647,177 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000146234 (exon 6) and 140 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 359 and early truncation 1 amino acids later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count