Thetargeting vector was constructed to insert a construct directly after the ATG start codon of the mouse Atf3 gene containing: Cre fused to the mutated estrogen-ligand binding domain (CreERT2), 1.2 kb of Atf3 3' untranslated region, a Simian virus 40 stop signal and a neomycin cassette flanked by two FLP recognition target sites. The neo cassette was removed from founders by crossing with Flp recombinase mice. It is a null allele. (J:278945)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count