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A loxP site was inserted upstream of exon 14 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 14 via homologous recombination. Recombinase mediated recombination removed exon 14 and the neo cassette. Real-time PCR analysis demonstrated a dramatic reduction of mRNA expression in the testes, lung, liver and kidney of adult homozygous mutant mice. (J:273740, J:272184)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
