The targeting construct introduced two loxP sites into the gene flanking exons 2-4, which encode elements of the CaMKK2 ATP binding domain, as well as the neo cassette, also flanked by loxP sites. (J:136219)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count