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EN
CRISPR/Cas9 endonuclease-mediated genome editing is used to insert loxP sites flanking exon 3. A single guide RNA with a spacer sequence and Cas9 endonuclease mRNA were introduced into NOD/ShiLtJ-derived fertilized eggs by pronuclear injection along with a single-strand oligonucleotide repair template with the loxP sequence (ATAACTTCGTATAATGTATGCTATACGAAGTTAT). (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
