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The transgenic vector was constructed by subcloning the mouse Bmncr cDNA into a plasmid containing the Lepr promoter. The vector was then purified and microinjected into C57BL/6J F2 mouse oocytes, and the oocytes were surgically transferred into pseudopregnant C57BL/6J dams. Two lines with higher levels of Bmncr expression were selected from 6 transgenic founders and bred in C57BL/6 strain for 6 generations to obtain offspring with a defined genetic background. One line with 10-fold overexpression of Bmncr was used for studies. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:270992)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
