The targeting vector introduced into intron 1 a loxP site, an FRT site, splice acceptor, IRES, hygromycin resistance cassette, polyadenylation sequence, zeomycin resistance cassette, and FRT site. An additional loxP site was isnerted downstream of exon 2. Cre-mediated recombination removed the selection cassettes and exon 2. (J:258043)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count