A loxP site together with an frt-flanked neomycin selection cassette was inserted in intron 1. Exon 2 contains the ATG translation initiation codon. A second loxP site was inserted distal to exon 2 in intron 2. The frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:277504)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count