The region encoding the laminin-like globular domain3 (LG3), part of the antiangiogenic fragment called endorepellin, was deleted by replacing exons 91-96 by the neo cassette, leading to a perlecan protein lacking 156 amino acids at the C-terminus. The deletion does not change the reading frame and the last exon of the gene is intact. (J:82809)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
Insertion, Intragenic deletion
--
1
3
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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