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A dominant-negative isoform of mouse Vps4b (Vps4b-EQ) cDNA with MycHis tag and bovine growth hormone polyadenylation sequence were placed under the control of a CAG promoter and lox-stop-lox sequence. VPS4b EQ has a modified E235Q in the encoded protein, which strongly inhibited signalling activity. (J:249954)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
