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All seven lysine codons in exon 11 were mutated to glutamine (p.K367Q, p.K369Q, p.K370Q, p.K378Q, p.K379Q, p.K383Q, p.K384Q) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 10. Cre-mediated recombination removed the neo cassette. The mutant protein mimics the acetylated form of the protein. (J:238814)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
