The single loxP site was inserted upstream of exon 12, and the loxP/FRT-flanked Neo cassette inserted downstream of exon 12. The target region is 2.2 kb including exon 12. Exon 12 contains the active site residues Ser-393 and Arg-365. (J:278285)
Basic Information
(C57BL/6NTac x 129S6/SvEvTac)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count