The C. elegans fat-2 gene was modified to optimize codon usage for mammalian cells and was expressed in mice under the control of a chicken beta-actin promoter (pCAGGS, which allows high-level and broad expression of the transgene in mice). (J:216334)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count