LoxP sites were inserted into the introns flanking exons 16~18, along with a Neo cassette flanked by Frt sites as a selectable marker. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:278266)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count