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An 8.5-kb genomic region extending from -3300 to +8200 with respect to the major transcription initiation site was replaced with a neomycin selection cassette. This deletion encompasses the minimal promoter, exon 1 and intron 1. RNase protection assays revealed that mRNA accumulation in various heterozygous tissue samples (liver, spleen, muscle, heart, testis, and brain) is about one half of that in wild-type samples. (J:275389)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
