Cep250^tm1Jzb

The p.R187* (CGA to TGA) mutation was introduced into exon 6. A loxP-flanked neomycin selection cassette was removed via cre-mediated recombination. The R187* nonsense mutation corresponds to the R188* mutation identified in a human nonsyndromic retinitis pigmentosa (RP) patient. (J:276510)