CRISPR/Cas9 mutagenesis induced deletion mutations in exon 4. Founder #4 with a 179-bp deletion was selected for further analysis. Complete elimination of encoded protein was verified in the hippocampus and other brain regions by Western blot analysis. (J:267186)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count