A gene cassette composed of floxed mutant human RET gene cDNA with the 51(C618F) variant, an SV40 intron polyA followed by mCherry reporter gene and a neomycin resistance marker (Neo) that was flanked by FRT sites was inserted into the first coding exon of the mouse Ret gene. The neomycin resistance cassette was removed via FLP-mediated recombination in the germline. (J:275428)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion
--
1
23
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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