A gene cassette composed of floxed human RET gene cDNA, an SV40 intron polyA followed by mCherry reporter gene and a neomycin resistance marker (Neo) that was flanked by FRT sites was inserted into the first coding exon of the mouse Ret gene. The neomycin resistance cassette was removed via FLP-mediated recombination in the germline. (J:275428)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count