Prdm9^tm3.1Kpgn

This mutation creates an alternative splice acceptor site 44 base pairs inside the 5'-end of exon 12, which codes for the entire zinc finger domain, causing a frameshift with a premature stop codon. As a result, the mutant protein contains the first 1381 amino acids, but lacks all of its zinc fingers and the ability to bind DNA at specific sequences. (J:277855)