A single distal loxP site was inserted within intron 1 and a loxP site together with an FRT-flanked neomycin selection cassette was inserted in intron 4. Cre-mediated recombination of the loxP sites surrounding exons 2-4 in the germline resulted in deletion of the loxP flanked sequences. (J:272796)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count