A 5.8-Kb fragment encoding the exon region was replaced with a neomycin-resistant gene cassette. Quantitative RT-PCR analysis confirmed the absence of mRNA expression in various gastrointestinal tissues (stomach, duodenum, jejunum, ileum, cecum, and colon) as well as in colonic epithelial cells of homozygous mutant mice. (J:258197)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count