A single loxP site containing an engineered EcoRV sequence was inserted 177bp 5' of exon 1, and a loxP/FRT flanked Neo cassette containing an engineered Spe1 sequence was inserted 270bp 3' of exon 1. The Neo cassette was removed via FLP-mediated recombination. (J:253757)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count