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The 7.2kb kb Tg4-42 transgene is designed with the Thy1 promoter driving expression of human Abeta 4-42 fused to a murine thyrotropin releasing hormone signal peptide. Transgenic mice express an N-truncated Abeta 4-42< (amino acids 4-42), a peptide shown to enhance Abeta aggregation in the brains of Alzheimer's disease (AD) patients. Founder line 2 has the highest expression of the transgene and sontains more than 20 copies in head-to-tail orientation, with the last transgene in reverse orientation. (J:275188)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
