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Exon 1 and approximately 1.5 kb of sequence upstream of exon 1 (promotor region) was flanked by loxP sites. A FRT-flanked puromycin resistance gene was inserted into intron 1 and removed via Flp-mediated recombination. Cre-mediated recombination removed the floxed region deleting the promotor region and transcriptional and translational start sites. Western blot analysis of testis lysates confirmed absence of protein in homozygotes. (J:277272)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
