Exon 1 and approximately 1.5 kb of sequence upstream of exon 1 (promotor region) was flanked by loxP sites. A FRT-flanked puromycin resistance gene was inserted into intron 1 and removed via Flp-mediated recombination. (J:277272)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count