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The human APOL1 kidney disease risk variant G1 contains a double missense mutation resulting in a serine to glycine change at amino acid 342 (S342G) and isoleucine to methionine change at amino acid 384 (I384M) and is able to lyse T. brucei rhodesiense, is under the control of the tetracycline responsive promoter element. The pound (#) sign is used when the line number is not specified or lines are pooled. The gene is only expressed in a tetracycline/doxycycline controllable manner when mice carrying this allele also carry a tTA or rtTA allele. (J:251848)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
