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This allele follows the meiotic cre-mediated recombination between the Pcdhbtm2Tyag and Pcdhgtm1.1Tyag alleles. The Pcdhbtm2Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette inserted upstream of the first gene, Pcdhb1, in the cluster. The Pcdhgtm1.1Tyag allele has an IRES, a lacZ gene cassette and a loxP site inserted into the 3' UTR of the last shared exon, gammaCR3, of the cluster genes. Recombination between the two results in the complete deletion of the Pcdhg cluster and the Slc25a2 and Taf7 genes located between Pcdhb and Pcdhg, as well as the inserted neo cassette and lacZ gene. (J:244163)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
