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A gene cassette composed of CreERT2 cDNA-BGH poly(A) followed by a floxed angiotensin converting enzyme (ACE)-Cre and Tn5-neo cassette were introduced into the second exon of the Gfra1 gene by gene targeting. This insertion deleted 95 nucleotides containing the 5'-UTR, the initiator Met and the signal sequences. Upon germ line transmission of the targeted allele, floxed ACE-Cre and Tn5-neo were selfexcised by ACE-Cre-mediated recombination in ES-cell-derived sperm. (J:272383)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
