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Using a bacterial artificial chromosome (BAC), transgene was created such that the cre recombinase is driven by Tbx6 regulatory sequences. The Cre recombinase expression cassette was inserted into into a bacterial artificial chromosome (BAC; clone# RP24239G12) containing Tbx6 locus with approximately 84 Kb upstream, 4 Kb of the open reading frame and 73 Kb downstream sequences at the 1st exon of Tbx6 such that 14 nucleotides (25th to 39th bases) including the ATG are removed. Four lines were generated with similar expression patterns. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:274134)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
