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The transgene contains the following elements: a 2.2 kb DNA fragment containing the promoter, exon 1 and (part of) intron 1 of the human skeletal muscle actin alpha 1 gene, the c isoform cDNA of the mouse peroxisome proliferative activated receptor gamma coactivator 1 alpha gene, and bovine growth hormone poly(A) signal sequences. The c splice variant incorporates a longer version of alternative 5' exon 1b, coding for a shorter alternative N-terminus of the peptide. Ten mouse lines (01-4, 02-5, 03-3, 03-6, 03-8, 04-1, 04-2, 04-6, 05-1, 10-4) were established. (J:138170)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
