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EN
The murine thymocyte antigen promotor (Thy1) drives the expression of the human APP (APP-751) cDNA bearing the Swedish double mutation K670N and M671L and the Indiana mutation V717F primarily in pyramidal neurons of the telencephalon and starting postnatally. Transgene copy number as assessed by Southern blotting is estimated to be about 20. Western blot analysis confirmed overexpression of the transgene in the hippocampus and cortex. Mice express on average 2-fold higher levels of amyloid beta42 than of amyloid beta40 in both cortex and hippocampus. (J:251735)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
