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IRES-lacZ reporter cassette as wells as a loxP site were inserted 171 bp upstream miR-204 stem loop and a loxP site plus a neomycin selection cassette were placed 365 bp downstream miRNA stem loops by homologous recombination in ES cells. The chimeric mice where crossed to flippase-expressing transgenic mice to remove Fret or F3 (a mutant of Frt) flanked lacZ and Neo cassettes, leaving two loxP sites immidiately flanking the miRNA stem-loops. (J:276908)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
