The targeting vector is designed to insert a loxP site upstream of exon 1 and an FRT-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 4. Cre-mediated recombination removed the floxed neo cassette. (J:235743)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count