A loxP site was inserted upstream of exon 5 and a floxed hygro cassette was inserted downstream of exon 5. Partial Cre mediated recombination in germinal cell line removed the hydro cassette and left the exon 5 flanked by loxP sites. (J:155437)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count