Tamoxifen-inducible cre/ERT2 and an FRT-flanked neomycin cassette were introduced to exon 1 of the mouse Mecom gene via homologous recombination in embryonic stem (ES) cells. Resultant mice were crossed with Flp-expressing mice to emoved the selection cassette. (J:101977, J:292941, J:310645)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count