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Using custom zinc finger nucleases, exons in the 5' one-third of the gene were targeted. ZFN RNA was microinjected into pronuclei of fertilized B6CBAF1 mouse embryos. This led to the establishment of a line with a biallelic 19 bp deletion (GGGTCTTCAGTCAAAAGAA) in exon 4 in the DENN domain of the encoded peptide. (J:276600)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
