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The Igh 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 (Rr153) flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a (Rr154) and hs3b (Rr155)). Enhancer hs4 (Rr156) lies downstream of the palindrome. This allele fully eliminates the left-side IRIS while maintaining all four core enhancer elements. (J:234741)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
