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A mutant form of Rps6kb1, containing a deletion of amino acids 246, truncation of carboxy-terminal 104 amino acids, and threonine to glutamatic acid mutation at position 412 (p70S6K D246/DCT104 T412E) is expressed from this construct under the control of a rat insulin I promoter. This mutant protein confers rapamycin resistance and increases in basal activity in transfected cells. Three mouse lines were generated, but only one line was studied further. (J:169347)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
