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Zinc finger nuclease (ZFN)-mediated genome editing was used in NOD.Idd9.3 zygotes to target the second coding exon of the Tnfrsf9 gene (target sequence CCCTCCAAGTACCTTctccaGCATAGGTGGACAGCCGAA). Progeny were sequenced at the locus targeted by the ZFN to map the insertion. Founder line 24 contains a two base-pair insertion (aa) at the target site, resulting in a premature stop codon. (J:274998)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
