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A neomycin resistance cassette was inserted upstream of a modified exon 13 in which insertion of a G bp results in a G to W nonsense mutation and frame shift truncation following 12 aberrant amino acids. This mutation mimics one identified in patients with acute myeloid leukemia. Cre-mediation removed the selection cassette. (J:274527)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
