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Valpha10.1 V-J and Vbeta8.3 V-D-J segments were amplified by RT-PCR from the C18 T cell clone. The V-J and V-D-J exon cassettes were cloned into TCR and shuttle vectors, and founder mice were screened by PCR for cointegration of the alpha and beta minigene constructs and by FACS for transgenic TCR expression. One founder was identified. These mice express an H-2Kd -restricted transgenic T cell receptor specific for the syngeneic CMS5 fibrosarcoma rejection antigen mutated ERK2(136-144). (J:271337)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
