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EN
ENU-induced A to C transversion at base pair 22,675,036 (v38) on chromosome 8, or base pair 31,556 in the GenBank genomic region NC_000074. The mutation corresponds to residue 859 in the mRNA sequence NM_001159774 (variant 1) within exon 9 of 22 total exons. The mutation results in an isoleucine to leucine substitution at position 243 (I243L) in both isoforms of the inhibitor of kappa-B kinase- (IKK-; alternatively, IKK-2) protein. (J:274802)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
