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The CRISPR/Cas9 system and sgRNA 5'-AATGCGAAACATGGTGGATC-3' was used to generate the mice. The CRISPR/Cas9 system generated a 23-base pair deletion at c.4158_4180del (NM_030695.2). The mutation is predicted to cause a frame-shifted protein product beginning after amino acid 1,290 of the protein and termination after the inclusion of 6 aberrant amino acids. (J:274652)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
